Powerful heart drug sharply cuts risk for patients on statins
Powerful heart drug sharply cuts risk for patients on statins
18 March, 2017, 01:40
Those who got Amgen's drug were 15 percent less likely to suffer a bad outcome, defined as heart attack, stroke, hospitalization for chest pain, placement of a stent, or death. The NLA's mission is to enhance the practice of lipid management in clinical medicine, and one of its goals is to enhance efforts to reduce death and disability related to disorders of lipid metabolism in patients. "The open question was, 'Does this way of lowering [cholesterol] reduce risk of coronary heart disease, '" says Sekar Kathiresan, a cardiologist at the Massachusetts General Hospital in Boston and the Broad Institute in Cambridge, Massachusetts, who was not involved in the study.
Meanwhile, another study is underway to test a similar drug called Praluent, and see whether it too lowers heart risks. "They asked for outcomes data and we gave them outcomes data", an Amgen spokeswoman said.
For patients like Susan Goodreds, whose insurance copay for Repatha is $356 a month, it's not an easy choice.
"The challenge for this industry is if the predecessor medicines are really good, and are now available for pennies, and are ubiquitous, it's really hard to come up with something that has sufficient incremental benefit and appeal to justify a price that is hundreds of times higher", Porges said.
The FOURIER Trial studied 27,564 patients who had a prior MI, ischemic stroke, or symptomatic peripheral artery disease and a LDL ≥70 mg/dL or a non-HDL-C ≥100 mg/dL with optimal statin therapy. But the study was terminated after only two years because the placebo group was at a disadvantage and having a higher rate of cardiac events. Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were created to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death.
"It is much more effective than statins", said Prof Peter Sever, from Imperial College London. In addition, the data showed that using the drug for a longer period of time increases magnitude of the risk reduction. Almost 10 percent of folks on Repatha had one versus more than 11 percent on the dummy drug. Since Praluent and Repatha are so similar in terms of cost and effectiveness, the markets are likely anxious that insurers will play hardball with Regeneron and Sanofi on pricing, too.
Okla. State Senator Hit With Child Prostitution Charges
The messages, which were found on the teenager's Kindle Fire tablet, later led to the charges against the Oklahoma senator. Senate officials said Shortey will still receive his $38,400 annual salary as a senator and will be allowed to vote.
"That's the biggest issue - whether they're worth all the money", Hlatky said of the drugs. This raises the concern that insurers might not be willing to remove numerous restrictions that they have placed on accessing Repatha unless Amgen is willing to give in on pricing.
In a trial of more than 27,000 patients, researchers found that taking monthly or twice-monthly injections of the medication, called evolocumab, on top of statins could cut cholesterol levels by nearly 60 per cent on average in patients with an underlying risk of cardiovascular disease.
The evolocumab study was funded by Amgen, the pharmaceutical company that makes the drug, which is marketed as Repatha. The two-year trial showed one heart attack or stroke was prevented for every 74 patients taking it.
A key secondary endpoint of the study narrows the list of bad patient outcomes to cardiovascular death, heart attack and stroke.
Shares of Amgen fell, while Regeneron was down 3.4 percent and Sanofi shares closed down 0.5 percent in Paris.
"During five years as a study investigator I have been impressed with the level of enthusiasm of heart patients for this treatment". The companies also are in a patent war over the drugs.
The baby and his six siblings, four boys and two girls ranging in age from 4 to 14, were placed in the care of family members. Though no one else was found in the auto , the Illinois Department of Conservation had a boat on the lake searching the water.
Atletico Madrid won the first leg 4-2 away to Bayer Leverkusen, so their passage to the quarter-finals was never really in doubt. Bottom club City produced spirited resistance but Rush finished them off after a length-of-the-pitch counter-attack.
South Korea banned imports of all USA poultry following the Tennessee bird-flu findings, according to its agriculture ministry. The other instances occurred at another commercial breeder and a backyard flock, according to a state press release .
Not only did she break the first leaked tax returns of Donald Trump , but she also handled a misgendered flub with humor. It also set a series best among viewers 25-54, averaging 1.4 million in the news demo.
Tiemoue Bakayoko scored the deciding goal 13 minutes from time with a delicious header, beating Willy Caballero at the front post. We have to admit that the German side didn't have any luck because they had several situations where they missed.
The official said that dozens of Somalis who survived, as well as three Yemeni traffickers, were taken to the city's prison. A Yemeni medical official in Hodeida said only 14 bodies had arrived so far, adding that women were among the dead.
The number of initial claims for unemployment insurance, a measure of new layoffs, rose by 5,801, or 151.7 percent, to 9.624. The number of unemployed increased by 797 to 4,500, while the number of employed individuals increased by 387 to 58,856.
At the time, the X9 discovery was unusual because black holes typically were not found in globular star clusters, like X9's. The scientists also found evidence of large amounts of oxygen in the system, an element found in white dwarfs.
Tesla raises $1.2 bln, tapping market again for funding
Especially considering that the image featured a auto that appeared to have been in the final phases of the design process. With that added to the tally, the maximum amount the company could potentially raise touches the $1.15 billion mark.
Fans Flock to Theatre To Watch Beauty & The Beast
Alan Menken, who wrote the original songs with Howard Ashman, provided the score and wrote three new songs with Tim Rice. But with Beauty and the Beast coming out today, it seems kids prefer another princess.
Amazon brings Alexa to the iPhone
Alexa in the Amazon app supports voice-driven skills already set up in the the Alexa app or on alexa. amazon .com. That app tracks voice search activity for the Echo but doesn't have any voice interaction capability of its own.
Emily Blunt to star with husband for first time
But both loved the script for A Quiet Place so much, they made a decision to go ahead and make it together . Paramount and Platinum Dunes are handling production, and Michael Bay is among the producers.
Trump budget goes big on border wall, short on agents
Funding for the government runs out in late April. "And so now Donald Trump wants the American taxpayers to pay for it". Building a wall - and having Mexico pay for it - was a regularly repeated campaign pledge of Trump's.
Tillerson to visit DMZ as part of S. Korean tour
Kishida said he had conveyed Japan's views to Tillerson for consideration during the policy review, but he didn't go into details. The regime change idea may resemble past actions like the 2003 invasion of Iraq that toppled Saddam Hussein.
March Madness: 5 can't-miss games to watch on Day 1
Brey's crew made only one of its final 10 field-goal attempts (a Colson layup at 2:07 to push Notre Dame ahead by three). The Republican has been friends with Notre Dame coach Mike Brey since he worked at the University of Delaware.