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Dan Woodruff Illustration Works Getty Images
Dan Woodruff Illustration Works Getty Images
21 March, 2017, 00:31
Trials showedRepatha taken alongside statins reduced the cholesterol levels by 60 per cent more than taking statins alone. It also proved safe - side effects were similar to those from a dummy drug.
Others said they expected more from the $14,000-a-year drug. The new study, published in the New England Journal of Medicine, offers some evidence, however, not as big a benefit as some doctors had hoped. After a follow-up period of around two years, it showed that the risk of heart attack, stroke and coronary revascularisation was cut by 27%, 21% and 22%, respectively. But looked at by themselves, deaths were not reduced by the drug.
"These results, I think, will mean the guidelines are adjusted slightly, but unless the price comes down it won't mean we give it to anyone by any means", said Professor Naveed Sattar, a metabolic medicine expert of the University of Glasgow, according to The Daily Mail.
Amgen research and development executive vice president Dr Sean Harper said: "This is a game changer for high-risk patients". The man-made antibody helps in cutting down the risk of cardiovascular and heart diseases related death in people by 20%.
Evolocumab is part of a new class of cholesterol-lowering drugs called PCSK9 inhibitors, which dramatically lower bad cholesterol, or low-density lipoprotein (LDL).
The drug was designed for people already taking the maximum dose of cholesterol-lowering statins but who had been unable to lower their cholesterol level sufficiently to ward off heart disease, in some cases because of an inherited genetic condition. The British Heart Foundation said the findings were a significant advance in fighting the biggest killer in the world. But he called the study "a solid outcomes trial" and said "we should celebrate" that it showed the drug is capable of reducing risk.
Aiming to address questions about its cognitive effects, researchers at Brigham and Women's Hospital in collaboration with Brown University and the University of Geneva ran cognitive tests on almost 2,000 people enrolled in a two-year study of the drug. Symphony Health data shows that commercial insurers rejected nearly three-fourths of PCSK9 requests past year, and Medicare coverage was denied at a rate of 61%. The companies also are in a patent war over the drugs. The drug is manufactured by the pharmaceutical company Amgen. That committee - 15 doctors and a pharmacist - reviews the information that federal regulators used to approve a drug and then decides whether it should be covered. JP Morgan's view is that, given the data and the current payer environment, physicians will choose to reserve treatment for patients with multiple comorbidities and relatively higher LDLs than the cutoff for FOURIER ( 70mg/dL). That can limit patient access.
"It's a small reduction for a super expensive drug", said Dr. John Mandrola, a cardiologist at Baptist Health in Louisville, Ky., and chief cardiology correspondent for Medscape, who wasn't involved in the study. After diving deeper into the data, we think it will be sufficient to change treatment guidelines, and our assumptions for net USA prices-going from roughly $10,000 today to $8,000 annually over the next couple of years as payers loosen restrictions-still hold.
Stubbornly high cholesterol is a key risk factor.
Among them, is a relatively new drug named Repatha which was cleared by the FDA in 2015. But once the drugmaker AbbVie produced a third option, Viekira Pak, with a similar cure rate, Express Scripts was able to negotiate a price discount and switched to covering only Viekira Pak.
They took the court wearing their practice uniforms because their game uniforms were still trapped under the plane. Michigan State vs Kansas scores and results will be posted here, which team will win? Self said on Saturday.
The film, directed by Oscar victor Bill Condon and based on the 1991 animated film, cost 160 million US dollars to make. Luke Evans says it took him some time to agree to play Gaston in the recently released " Beauty and the Beast ".
The team that will most likely stand in its way of accomplishing that goal is my choice to win it all, the Arizona Wildcats. The 'Cats also happen to be red-hot right now, winning their last 11 games and capping off another SEC Tournament title.
"We perform hundreds of tests every year to help make the Netflix member experience better", a spokeswoman for Netflix said. Netflix already does this with many shows that have intros that are at the top of the show.
The referee may not have been ideal but if a team is unable to protect a 4-0 lead perhaps the players should take the blame... Former Juventus fullback Gianluca Zambrotta insists they're on the level of Barcelona.
The brand will also be on hand at the Canada Blooms festival, handing out 50,000 Veseys wildflower seed packs to visitors. General Mills have refuted the claims in a statement on Facebook , saying that their seeds are bee friendly.
The Chinese say the powerful radar in the Terminal High Altitude Area Defence ( THAAD ) system is a threat to Beijing's security . Trump has been a frequent China critic, and the encounter could be crucial to setting the tone in the big-power relationship.
The Redmi 4A was the cheapest of the lot, and was priced at RMB 499, which translates to approximately Rs 5,000. The camera combination is also same on the both, a 13-megapixel rear camera and a 5-megapixel front camera.
Gold Prices Steady as Oil Falls
The continued build-up of the USA supply of crude has more than countered the production cuts agreed to by members of OPEC. The output cut has not done much to end the supply glut and global oil demand continues to be lower than the supply.
Shad Khan makes Forbes list of richest people on planet
Jim Davis, the CEO of the Boston-based New Balance, finished in a tie for 315th place with a net worth of $7.1 billion. The magazine estimated the worth of the Mar-a-Lago resort in Florida rose $25m due to post-election exposure.
"Beauty and the Beast" shatters Box Office records
In the film, the handsome Belle is imprisoned in an enchanted castle by a fearsome Beast , who soon falls in love with her. It continued with the Film Censorship Board in Malaysia requesting Disney to cut the moment from the film completely.
Electronics banned from some flights to US
The prohibition will begin starting with flights departing to and arriving from New York, Chicago, Detroit and Montreal . Delta Air Lines and United Airlines, the only two U.S. carriers which operate to the Middle East, decline to comment.
Spurs win battle of reserves over Warriors
Chris Paul scored a season-high 33 points for the Clippers, who fell two games behind Utah in the race for a top-four seed. Minnesota reserve Nemanja Bjelica had his fourth double-double in his last seven games with 16 points and 10 rebounds.
J. Denny Weaver: Ryan's health care bill reveals his values
She also wants an improved proposal that would cover more Americans and offer better Medicaid benefits than the current GOP plan. John Katko, from a closely divided district in upstate NY , who cited inadequate insurance access and cost controls.
Syria's war : Forced evacuations begin in Al Waer
But the opposition decries them as a tactic of forcibly displacing people who oppose Assad after years of bombardment and siege. He had said earlier this week that fighters who decide to stay in al-Waer can benefit from a government amnesty issued earlier.
Coutinho: Liverpool need to beat Man City
MANCHESTER - Roberto Firmino starts for Liverpool in their Premier League game against Manchester City on Sunday. We know it's a different game when you play against a top team, who let you play football and we'll be ready.
Syria: Israeli warplanes strike targets in Syria
According to reports on Syrian opposition websites, Assayed was a senior officer in country's air defense system. Arab media reported that the target of Israel's strikes was a Hezbollah weapons convoy heading toward Lebanon.
West Ham 2-3 Leicester: Foxes revival continues
They seem to be on the ball with things and I think they'll do what they did so well last season if they come to West Ham . He has now guided Leicester to victory in each of his last four games since taking over from Claudio Ranieri.
Cavs' Love to make return vs. Jazz
The Cleveland Cavaliers dug deep and beat the Utah Jazz at home on Thursday night behind an MVP caliber LeBron James performance. I got the proper rest, got the strength back, so now, it's just getting out there. "Some days are diamonds, some days are stones.